Grant‐in‐Aid for Scientific Research on Innovative Areas
(Research in a proposed research area)

Novel measurement techniques forvisualizing 'live' protein moleculesat work

Genomic DNA encodes the amino acid sequences of proteins. In the evolution of life, random mutations and natural selection have made the proteins molecular machines that autonomously form stable tertiary structures, for their functions as catalysts, sensors, actuators, and scaffolds in organisms. The 3D structures determined by X-ray crystallography are inevitably static, but they provide convenient explanations of the protein functions, as if they were macro-scale machines. However, most structural biological techniques cannot properly convey the dynamic aspects of protein structures. In this research program, we aim to develop innovative measurement techniques, to vividly describe protein structures at their sites of action.