九州大学 生体防御医学研究室 構造生物学分野 TRUE COMBINATION OF XRAY,NWR AND EM FOR STURUCTURAL BIOLOGY

Research Projects involved

Grant-in-Aid for Scientific Research on Innovative Areas

Novel Measurement techniques for visualzing 'live' protein molecules at work

period: FY2014 ~ FY2018
http://ugoku-tanpaku.jp/

Summary

Genomic DNA encodes the amino acid sequences of proteins. In the evolution of life, random mutations and natural selection have made the proteins molecular machines that autonomously form stable tertiary structures, for their functions as catalysts, sensors, actuators, and scaffolds in organisms. The 3D structures determined by X-ray crystallography are inevitably static, but they provide convenient explanations of the protein functions, as if they were macro-scale machines. However, most structural biological techniques cannot properly convey the dynamic aspects of protein structures. In this research program, we aim to develop innovative measurement techniques, to vividly describe protein structures at their sites of action.

Organization
  • Daisuke Kohda, Professor, Kyushu University (Leader)
  • Toshio Ando, Professor, Kanazawa University 
  • Masahiro Shirakawa, Professor, Kyoto University 
  • Noritaka Nishida, Assistant Professor, The Univ of Tokyo
  • Yuji Sugita, Chief Scientist, Riken
  • Tomoya Tsukazaki, Associate Professor, Nara Institute of Science and Technology

A related center in Kyushu University

Research Center for Live-Protein Dynamics

Research Projects
in the past

Global COE Program

Cell-fate Decision: Function and Dysfunction in Homeostasis

period: FY2007 ~ FY2011
http://vsb.bmr.kyushu-u.ac.jp/GCOE/english/

Summary

This program will consolidate and expand the outcomes and the concepts of the 21st Century COE Program “Integrative Life Sciences -Post-genome Research of Systemic Life Sciences” undertaken in Kyushu University for 5 years from 2002 (Program leader: Yukio Fujiki). The objective is to establish a new educational and research center of the highest international level related to "clarification of the mechanisms underlying the cell-fate decision that support the homeostasis of individuals such as humans and construction of a basis for medical applications of stem cell biology."

Organization
  • Program Leader: Prof. Yukio FUJIKI
  • Graduate School of Systems Life Sciences, Kyushu University, 5 researchers
  • Graduate School of Medical Sciences, Kyushu University, 10 researchers
Our contribution to the program

Structural Biology Laboratory, Post-Genome Research Center

Target Protein Project

Target Protein Project

National Project after Tanpaku3000
period: FY2007 ~ FY2011

Project1

Target: NOX (NADPH oxidase) family
Project Leader: Hideki Sumimoto, Professor, Kyushu Univeristy
Member: Fuyuhiko Inagaki, Professor, Hokkaido Univeristy
Member: Daisuke Kohda, Professor, Kyushu Univeristy

Project2

Target: Dock2 (CDM family)
Project Leader: Yoshinori Fukui, Professor, Kyushu Univeristy
Member: Shigeyuki Yokoyama, Project Director, Riken
Member: Masakatsu Shibasaki, Professor, the Univeristy of Tokyo
Member: Daisuke Kohda, Professor, Kyushu Univeristy

Grant-in-Aid for Scientific Research on Innovative Areas

Transient Macromolecular Complexes

period: FY2009 ~ FY2013
http://ishimada.f.u-tokyo.ac.jp/public_html/tmc/

Summary

English version is not available

Organization
  • Ichio Shimada, Professor, the University of Tokyo (Leader)
  • Daisuke Kohda, Professor, Kyushu University
  • Takashi Funatsu, Professor, the University of Tokyo
  • Itaru Hamachi, Professor, Kyoto University
  • Masahiro Shirakawa, Professor, Kyoto University
  • Haruko Hayasaka, Assistant Professor, Osaka University

Grant-in-Aid for Scientific Research on Priority Areas

Molecular Soft-interactions Regulating Membrane Interface of the Biological Systems

period: FY2003 ~ FY2008

Summary

English version not available

Organization
  • Hideo Akutsu, Professor, Osaka University (Leader)
  • Tatsuya Haga, Professor, Gakushuin University
  • Masahiro Shirakawa, Professor, Yokohama City University
  • Daisuke Kohda, Professor, Kyushu University
  • Yuji Sugita, Lecturer, Tokyo University
  • Ichio Shimada, Professor, Tokyo University
  • Saburo Aimoto, Professo,r Osaka University
  • J. H. Tame, Professor, Yokohama City University
  • Hiroyuki Toh, Professor, Kyoto University

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